An integrative overview of the cannabinergic system and mental health

Oscar E. Prospéro García, Pavel E. Rueda Orozco, Octavio Amancio Belmont, Alejandra E. Ruiz Contreras, Mónica Méndez Díaz



Background. The endocannabinoid system (eCBs) is one of the modulatory systems widely expressed in the brain. It consists of receptors expressed in the cytoplasmic (CB1 and CB2), the mitochondrial membrane (CB1), and the endogenous ligands known as endocannabinoids, such as anandamide, 2AG and oleamide. CB1 has been found in excitatory and inhibitory neurons in the pre- and post-synaptic membranes. It is expressed in several brain areas such as the hippocampus, dorsal, and ventral striatum, amygdala and prefrontal cortex. The eCBs has been involved in the regulation of learning and memory, mood, energy balance, sleep, and drug addiction.

Objective. Integrate existing information about the eCBs and its role in brain function and mental health.

Method. Review of the information of basic and clinical relevance obtained from indexed scientific journals (PubMed/Medline, Scopus).

Results. Basic and clinical research on eCBs related to central nervous system function is described.

Discussion and conclusion. At present, the study of eCBs is of importance. The development of drugs that affect this system may be clinically useful to control different debilitating diseases. This is an area of interest to the scientific community and health care providers.


Cannabinoid system; endocannabinoids; cannabinoid receptor 1; cannabinoid receptor 2; mental health

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